Asba is sweet and carcinogen?Can sugar -free cola still drink?

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On June 29, local time, Reuters reported that the two sources revealed that "Asba Sweet" will be first listed by the International Cancer Research Agency (IARC) of the Cancer Research Institution (IARC) of the World Health Organization (WHO) in July this year."Materials that may be carcinogenic."

It is nothing new about the safety of sugar replacement. As one of the most widely used sugar in the world, Asta has been the main component of many foods and drinks for decades, including the most famous sugar -free sugar -free non -sugar -free non -sugar -free non -sugar -free.Cola, EXTRA mouth gum, etc.

In September last year, the top issue BMJ released a study that used the use of Asba Sweet, Anspelli potassium, and trichlorite.However, according to the explanation of the US FDA official website on May 30, including Asba Sweet, "According to the existing scientific evidence, the sweetener authorized by FDA is safe for ordinary people under certain use conditions."

The results of this IARC review may once again set off a wave of discussion on sugar, and even affect the industrial structure.As soon as the news came out, domestic consumer brands quickly clarified the relationship with Asba sweetly.On the evening of June 29, the Georological Forest posted a Weibo saying that its entire line of products did not contain Asba sweet.The person in charge of Naixue’s tea said to the outside world that it had announced that all products had been upgraded to the natural sugar "Luo Han Fruit Candy" last year.

Picture source: Rui Jing

IARC provokes dispute again

According to different standards, if it belongs to sugar, whether it produces heat, artificial synthesis, or natural existence, sugar can be divided into different categories. Among them, Asba sweet belongs to artificial synthesis, non -nutrition (0 calories), non -sugarSweetter, long -term considered help to reduce the intake of calories and sugar.

However, WHO issued a report in May this year stating that it is recommended not to use non -sugar sweeteners to control weight, or to reduce the risk of non -infectious diseases.Unlike WHO just reminding, IARC may directly attribute Asba to "may cause cancer."

According to Reuters, this ruling depends on the early this month that external experts of the organization have been widely discussed, but they will not define the safe dose -this work will be by the World Health Organization Food Additive Expert Committee (JECFA)Responsible, including reviewing Asba’s daily acceptable intake and dietary exposure evaluation.

According to IARC’s classification of carcinogens, it is divided into "carcinogenicity to people", "likely carcinogenic" and "possible carcinogenic". Although it is only included in the minimum, but the previous whip of WHOSo that it caused a lot of opposition in the industry.

"The International Cancer Research Institution is not a food safety institution." Francis Huntwood, Secretary -General of the International Sweetter Association, emphasized in a statement yesterday that Asba Sweet is one of the most thorough research in history, 90 worldwide, 90 worldwideMultiple food safety institutions claim that it is safe."

This is not the first time IARC has caused controversy.Earlier, the agency had included red meat, coffee, and mobile phone -related radiation in the "carcinogenic list". It was considered to send unnecessary alerts for some unavoidable substances or situations when the evidence or risk was insufficient., Even forced the manufacturer to re -formulate or replace the formula without the "real hammer".

The sweetness of Asba is even more so.Since the 1980s, it has been widely used as food sweeteners and used in products such as carbonated drinks, gum, oatmeal, and cough drugs. It is also a sucrose alternative to consumer groups such as diabetic patients, obesity, and elderly people.According to the data of Shangpu Consulting Group, artificial synthetic sugar occupies 68.5%of the sugar replacement market share, while Asba sweet accounts for 36.2%of the artificial synthetic sugar substitute market share, the market size is about 4.7 billion US dollars.

Zhou Yan, director of the clinical nutrition of the Second People’s Hospital of Zhengzhou City, told the "medical community" that the previous proposal was to remind the public to correctly understand non -sugar sugar, avoid excessive use and think it can make people "healthier" "healthier"Essence"But Asba is very small in food, and it is safe to use within the range of recommended intake."

According to Reuters, since 1981, JECFA has always stated that Asba is safe to eat in acceptable daily limits.For example, adults weighing 60 kg, the daily sweet intake of Asba must reach the content of 12 to 36 cans of sugar -free soda before facing risks. This also gets national regulatory agencies including the United States and Europe.Wide recognition.

As of the 29th, the New York Stock Exchange was closed, and fell 0.49%to $ 60.03.After Reuters disclosed the relevant information, Kate Lotman, executive director of the Council of the International Beverage Association, said that the move "may not be unnecessary to mislead consumers to consume more sugar instead of choosing safe sugar -free and low sugar choices."The American Beverage Association also stated in a statement, "Food safety agencies around the world, including FDA, continued to discover that Asba sweet is safe. This fact makes us confident in our products."

However, the British "Guardian" disclosed that IARC’s decision was based on the collection of 7,000 research references on Asba sweets, and included 1,300 studies in the materials packet evaluated by experts.

About Asba’s sweet carcinogenic study

"Everyone licensed by the state is safe according to regulations. But some products may have some health impacts on some people, and have academic controversy, such as Asba Sweet." Fan Zhihong, Associate Professor of Food at the School of Food, China University of Agricultural UniversityIn an interview with Xinhua News Agency, "government agencies of various countries are cautious about this, but they have not banned Asba’s sweetness."

The controversy mentioned by Fan Zhihong includes the research on Asba’s sweetness in various diseases.For example, in 2013, scholars from Changsha Medical College of Hunan concluded in the study of "The Influence of Asba Sweet on the Immunity of Diabetes Mice".Immune response leads to a decline in immunity and the possibility of carcinogenic. "

On March 24, 2022, a large -scale queue study from France found that artificial sugar Astaba sweet and Ansaimi may increase the risk of cancer.This experiment is also considered to be an important basis for IARC’s decision. The test incorporated in over 100,000 subjects, showing that the overall risk of cancer users with the overall cancer users increased by 1.13 times, and breast cancer (1.22 times) andObesity -related cancer (1.15 times) risk is higher.

In addition, there are many basic studies on Asba’s sweetness that it may have an impact on various systems of the human body, including causing emotional disorders, mental stress, and depression; the mother absorbs Asba sweet and children’s autism during pregnancy.Related; long -term use will affect the brain and cerebrus cortex, lead to neur variability, change the function of neuron cells, and disturb the balance, learning and memory in the body.

However, the reason why Asba is still recognized and widely used by mainstream because most of the evidence -based medical grades of most studies are not high, and crowd tests only reflect that Asba’s sweetness is "possible" with certain diseases.Causal relationship.

And Asba’s sweet carcinogenic research is more concentrated at the level of animal trials.In response to the aforementioned French epidemic survey, the European Food Safety Administration questioned the design of the test.The industry generally believes that Perhaps Asba has an uncertain carcinogenic risk, but at least no study can finally determine that there is a clear relationship between the two.

"Whether it will eventually be listed as a carcinogen, it is meaningless to remove the toxicity of the dose." Zhou Yan said, "Asba does not provide any nutritional ingredients, and it is mostly used in deep -processed foods such as beverages.Of course the best. But if it is only moderate, at least it does not think that it will have too much effect on health, and sugar -free cola can continue to drink. "

Zhou Yan said that the dietary design of patients such as diabetes and other patients will also moderately match some sugar -free biscuits, including some anthampnons, such as anemia, which also contain sugar, "compared to sucrose," compared to sucroseThey will not cause blood sugar fluctuations, and supplementation of sweetness can also enhance the compliance of patients. "

According to Reuters, after the IARC meeting, JECFA has launched an assessment of Asba’s sweet dose, which was announced on July 14 with "whether to cause cancer".

Ruan Guangfeng, the director of the business department of the Kexin Food and Health Information Exchange Center, said in an interview with "Tide News" that there are legends (Asba Sweet) are 2B carcinogens, which may cause cancer as the carcinogenic level of pickles, but this may be carcinogenicThe conclusion that even the animal laboratory evidence is not enough for the time being, and it cannot shake the sweet status of Asba.

Can sugar be consumed by "hitting"?

Affected by Asba’s sweet public opinion storm, the stock price of A -shares such as A shares such as red moss glycol, which is a substitute, collectively rose collectively.As of the afternoon of the 30th, the concept sector of the substitute replacement rose 5.24%as a whole.However, if it is evaluated by the sweet indicator of Asba, the safety risk of red moss alcohol seems to be better.

Big Moss Glycol is a natural nutritional sugar, which is mostly used for foods such as candy, chocolate. In a study in "Natural Medicine" on February 27 this year, cardiovascular experts from the Cleveland Clinic in the United States reminded that the moss is moss.The risk of glycosol and cardiovascular diseases such as myocardial infarction and stroke is related.

In this study, the team first conducted a survey of nearly 1,200 patients who received the risk of heart disease, and found that the blood concentration of a variety of diverse meteronicides was higher in blood analysis.The increase in risk of vascular events.Among them, moss glycol is particularly obvious, and it observes that it causes thrombosis to form.

Slip sucrose was not spared.This is a kind of artificial sugar with zero calories. In 2022, it was published in "Cells" and found that daily intake of tricychrotose can change the composition of microorganisms in the mouth and feces, and will damage the blood sugar reaction.

Animal test published in "Nature" on March 15 this year has caused a blow again: trichlorotonose has affected mice’s T cell proliferation, which may reduce the ability of the immune system to cope with cancer.Researchers emphasized that "it is difficult to obtain the level of three sucrose in the experiment in daily food, but it is still recommended to reduce foods containing trichlorite containing trichlorite."

Although the controversy of sugar replacement is constant, the current consensus is questioning the safety of sugar generation, whether it is more complicated to the human body’s metabolism, etc. It may be necessary to conduct long -term tracking and testing of several generations of consumers in order to know the results of the exploration.Can not be used for food.At a forum in 2021, Chen Junshi, an academician of the Chinese Academy of Engineering, also mentioned that "sweetener is not a negative term and has become an indispensable part of the modern food industry."

Zhou Yan said that artificial sweeteners, as a short -term method to help some people reduce the use of sugar, is generally safe.Compared with the "disease risk" with low evidence level, it is more important to pay more attention to the impact of sugar on the long -term ingredients of people. Especially for children, sugar can make taste buds used to sweetness, which causes excessive use and even replace drinking water.

Fan Zhihong once stated in his public account article that sweeteners can have an exciting role in the brain, leading people to eat more high -calorie foods.After taking more sweeteners, the risk of obesity may be greater than ordinary people.Therefore, even if it is "0 sucrose" food, pay attention to the appropriate amount of intake.

(Learn more, please pay attention to the "medical industry" WeChat public account yixuejiezazhi, download the medical doctor station app on the mobile side)

Source: Medical Community

Editor -in -chief: Qian Wei

Edit: Zhao Jingjing

*"The medical community" strives to publish the professional and reliable content published, but does not commit a commitment to the accuracy of the content; please check or use it as a basis for decision -making.

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